The ethanol seed extract of Achras zapota Linn. was evaluated for hepatoprotective activity in rats with experimental liver injury induced by carbon tetrachloride (CCl4) (1ml/kg body weight). The seed extract at the doses of 200 and 400mg/kg was administered for 5 days and the hepatoprotective activity was assessed by estimating the levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), bilirubin, glutathione (GSH), superoxide dismutase (SOD) and total proteins in the rats. Silymarin was used as the standard hepatoprotective drug. The extract showed significant (P<0.05) dose-dependent hepatoprotective activity by decrease in the serum level of SGOT, SGPT, bilirubin and lipid peroxidation while the total protein, glutathione (GSH) and superoxide dismutase (SOD) levels were significantly increased in the animals received the extract at the higher dose level. The results suggest that the ethanol seed extract of Achras zapota possesses excellent hepatoprotective effect against CCl4 induced hepatocellular damage in rats.
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